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Physiological Mechanisms Underlying Perceptions of Nausea and Stomach Fullness       08/07/05 04:33 PM Edit Reply Quote Heather Reged: 12/09/02 Posts: 7799 Loc: Seattle, WA Sickness and Satiety: Physiological Mechanisms Underlying Perceptions of Nausea and Stomach Fullness Max E Levine PhD Department of Internal Medicine Section of Gastroenterology, Medical Center Boulevard, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA. Current Gastroenterology Reports 2005, 7:280-288 Published 1 August 2005 Abstract The pathophysiology of nausea and the physiological mechanisms underlying perceptions of stomach emptiness and fullness are not clearly understood, but several potentially important factors have been identified. Gastric dysrhythmias are believed to contribute to the subjective experience of nausea and may also be involved with perceptions of stomach emptiness, hunger, and even dyspepsia symptoms like bloating and early satiety. Normal gastric neuromuscular function is more evident in the absence of nausea and is also thought to be related to feelings of satiety or comfortable stomach fullness. Autonomic and endocrine influences may also play a critical role in the pathophysiology of nausea and abnormal perceptions of stomach emptiness or fullness. Achieving a better understanding of the gastric neuromuscular and neurohormonal influences on perceptions arising from the viscera may prove invaluable in the development of novel treatments for such conditions as unexplained nausea, functional dyspepsia, and obesity. http://www.biomedcentral.com/1522-8037/7/280/abstract -------------------- Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook! Print     Remind Me     Notify Moderator

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