When I had a uterus it wasn't tilted & I had IBS. I have been uterus free for several years now & still have IBS. Tilted may put pressure on the colon to exascerbate the IBS and so does adhesions from surgery I believe. Let me know how the Zoloft works for you & when it starts to work. My doctor put me on Zoloft 2 weeks ago for daily anxiety attacks. He started with 25mg for one week then 50 mg for the second week. I go back next week to evaluate it. I don't feel the dose is strong enough for me but it can make you nauseaus, at least it did me but I'm over that part now. I feel a little less anxious but not anywhere near where I had hoped. But then everyone is different.