I was on Zoloft for a couple years (have been off of it for a couple years) for depression/anxiety. It really did help with the IBS-D, too. I read about Seretonin on the internet and found that brisk walking or and exercise also helps release seretonin naturally. So I started walking regularly and it really helped. I didn't want to take the Zoloft for the rest of my life and I was eventually able to get off it with therapy. Now I try to regulate things with exercise and diet. Although, with the cold weather it's hard to get out and walk. I was initially put on Paxil, but it didn't agree with me.....made me even more anxious, etc. So they put me on a very low dose of Zoloft. You may want to check into it. It may be a way to get things on an even keel and allow you to work things out so that you can eventually get off of it like I did. Hope this helps.