The comments were directed to capricorn1942's link to a news article on the MRI study that you and Gaga posted links to. The point was that while the MRI study was interesting it did not show that all IBS pain is a result of down regulation or inhibition of the pain cognition control centers in the brain. This is further confirmed by your comments on studies that show CRF signals mast cells to release histimine contributing to pain. In other words CRF contributes to pain without directly effecting the pain control centers in the brain. It wasn't a discussion about the validity of brain-gut dysfunction theory
-------------------- STABLE: ♂, IBS-D 50+ years - Science of IBS