In North America you will likely have difficulty getting a GI to prescribe it for you. The FDA says Lotronex has not been shown to be effective for males. In addition some studies claim it appears to be more poorly absorbed by men compared to women. Even in women because of infrequent but serious gastrointestinal adverse events it is restricted to those women patients for whom the benefit-to-risk balance is most favorable.
However, there are a few reports that it has been used with limited success on men in the UK. You might have to go to the UK to find a GI doc who will prescribe it for you. Also, you might show this relatively recent research article to your GI doc. It examined the use of Lotronex on men using 662 subject and concluded "Alosetron 1 mg twice daily provided adequate relief of IBS pain and discomfort, and improved stool consistency in men with diarrhea-predominant IBS"
Have you tried Heather's Eating for IBS diet approach to managing your IBS? You might get some dietary guidance from people on the board if you post the meals and snacks you have eaten for the past 2-3 days.
-------------------- STABLE: ♂, IBS-D 50+ years - Science of IBS
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Re: Male wanting to take Lotronex - help!
Also, you might show this relatively recent research 
