CMW, from what I can read, probiotics should not have any major negative effect on you. However, everyone is different, and reacts differently to things. Are you taking other medication that could be causing an interaction? As well, if you have a fungal/yeast overgrowth, the good bacteria may be pushing out the overgrown yeast and you may be experiencing a die-off effect, more or less. Also, when I took probiotics with FOS, I had D reaction. As soon as I stopped, I felt much better.Probiotics without the FOS don't bother me at all. Maybe stop the brand you're taking and see if you don't feel better. Try another type of probiotic. Not one size fits all, I'm sure.
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