Possibly stress started it slowly but my IBS-D didn't get full blown until back in 1980 I was given a med to clean out my colon for a test and from that week on the D never cleared up. And of course that meant the panic attacks and agoraphobia came on the heels of constant worry about D in public. What a vicious cycle this disease can be. It makes me fill up with tears to think that until I found this website I knew I was doomed to a miserable life. And some days it did not seem worth living if I had to live that way. For me Heather's diet was my key out of prison.