Usually taking it after the first BM makes it my only BM. UNLESS I've seriously overeaten or eaten unusually high fiber/higher fat meals the day before. Lately I have been having maybe one more small BM at night before bedtime. Not sure what that's about but it doesn't bother me, no cramps or pain. But if I do have a day when I have more morning BM's the immodium doesn't stop them completely, just slows them down.