I definitely take immodium the night before, and often also immediately after I awake. This definitely helps on days when you have to do something and can't afford to have an attack. Unfortunately, it does constipate me but having lived with daily D for a long time...it's somewhat of a relief to not miss out on something important because of ibs. I'm still learning how to balance the sf,if, and immodium. I definitely feel more in control than I used to! Hope this info helps... Terri