They cause a synergestic effect in the body. They are both doing the same thing, I guess, so it increases your body temperature (according to my doc). Both, my regular doctor AND my GI doc said that I can only take one or the other and I keep switching because I don't know which one works better. I sleep better with the Elavil but I am still having attacks. The elavil is supposed to relieve abdominal pain AND diarrhea, just like the Levsin, but it doesn't work as good in that area to me. I was on it for a year, before, and I didn't even have the Levsin then and it worked for me then just fine. I stabilized and was doing well. But, then when I was able to sleep on my own I quit taking the Elavil and have been having problems ever since. So, maybe it will just take a long time for it to start working again, like last time. Who knows...... Michelle
-------------------- IBS-D. Hiatal Hernia, GERD
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