Motilium?
#87542 - 07/07/04 08:17 PM
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ibsgrl
Reged: 04/18/04
Posts: 1060
Loc: Canada
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Hi all - My doctor mentioned a drug called Motilium to me and said it may be an option if I continue to stay the same way I am now. I am C, with pain & bloating. Has anyone ever heard of it? I live in Canada, don't know if it available in the states - its rx in Canada. Maybe there could be another name for it, as I can't find much info on it. I am wondering if it is an antispasmodic or what and if it could help any of my symptoms....opinions?? I was under the assumption that antispasmodics were for D-predominants, or A's. But I am without a doubt, 100%, no hesitation a C. *sigh* Anyway thanks for reading/listening!
PS - Leigh, I saw you're on Librax? Am I correct that you are a C? Is it also an antispasmodic?? I am going to go look it up anyway though..
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Re: Motilium?
#87594 - 07/07/04 09:39 PM
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gigi
Reged: 03/21/04
Posts: 1442
Loc: South Texas
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I haven't heard of Motilium, but I will do a search. There is a possibilty that it could help me also, I am a C too.
IT doesn't matter if I am an A,D orC, I still have spasms and pain every day! I am tired of the Levsin playing around with my eyesight! Glad you brought this up.
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I did find this. It is not available in the US though.
Domperidone (Systemic) The Following Information Provided by Thomson MICROMEDEX -------------------------------------------------------------------------------- Overview ' Precautions & Side Effects -------------------------------------------------------------------------------- BRAND NAMES: In Canada Motilium Description Domperidone ( dom-PER-i-done) is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Domperidone is to be given only by or under the immediate supervision of your doctor. It is available in the following dosage forms:
Oral Tablets (Canada) Proper Use of This Medicine
Dosing - The dose of domperidone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of domperidone.If your dose is different, do not change it unless your doctor tells you to do so.
The number of tablets of that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking domperidone.
For oral dosage form (tablets): Treatment of gastrointestinal motility disorders: Adults10 milligrams (mg) three to four times daily. Some patients may require higher doses up to 20 mg three or four times daily. Nausea and vomiting: Adults20 milligrams (mg) three to four times daily.
Missed dose - If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage - To store this medicine:
Keep out of the reach of children. Store away from heat and direct light. Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.
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this too
#87598 - 07/07/04 09:51 PM
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ibsgrl
Reged: 04/18/04
Posts: 1060
Loc: Canada
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MOTILIUM® tablets
SCHEDULING STATUS Schedule 2.
PROPRIETARY NAME (and dosage form)
MOTILIUM® tablets
COMPOSITION Each tablet contains 10 mg domperidone.
PHARMACOLOGICAL CLASSIFICATION A.5.7.2 Anti-emetics and anti-vertigo preparations.
PHARMACOLOGICAL ACTION Domperidone is a dopamine-receptor blocking agent. Its action on the dopamine-receptors in the chemo-emetic trigger zone produces an anti-emetic effect. Domperidone does not cross the blood-brain barrier to any appreciable degree and so exerts relatively little effect on cerebral dopaminergic receptors. Domperidone has been shown to increase the duration of antral and duodenal contractions to increase gastric emptying. Domperidone does not alter gastric secretions and has no effect on intracranial pressure or on the cardiovascular system. Domperidone is rapidly absorbed, with peak plasma concentrations at approximately 1 hour after oral administration. The absolute bio-availability of oral domperidone is low (approximately 15%) due to first-pass hepatic and intestinal metabolism. Domperidone is 91 to 93% bound to plasma proteins. The plasma half-life after a single oral dose is 7 to 9 hours in healthy subjects but is prolonged in patients with severe renal insufficiency. Domperidone undergoes rapid and extensive hepatic metabolism by hydroxylation and N-dealkylation. In vitro metabolism experiments with diagnostic inhibitors revealed that CYP3A4 is a major form of cytochrome P-450 involved in the N-dealkylation of domperidone, whereas CYP3A4, CYP1A2 and CYP2E1 are involved in domperidone aromatic hydroxylation. Urinary and faecal excretion amount to 31% and 66% of the oral dose, respectively. The proportion of drug excreted unchanged is small (approximately 1% of urinary and 10% of faecal excretion).
INDICATIONS MOTILIUM is indicated for: - Delayed gastric emptying of functional origin with gastro-oesophageal reflux and/or dyspepsia. - Control of nausea and vomiting of central or local origin. - As an anti-emetic in patients receiving cytostatic and radiation therapy. - Facilitates radiological examination of the upper gastro-intestinal tract.
CONTRA-INDICATIONS MOTILIUM is contra-indicated in patients with known hypersensitivity to domperidone. MOTILIUM should not be used whenever stimulation of gastric motility is to be avoided or could be harmful, eg. in the presence of gastro-intestinal haemorrhage, obstruction or perforation. MOTILIUM is also contra-indicated in patients with a prolactin-releasing pituitary tumour (prolactinoma). The safety of use during pregnancy and lactation has not been established.
DOSAGE AND DIRECTIONS FOR USE Acute conditions (mainly nausea, vomiting, hiccup) Adults: Two tablets (20 mg) 3 to 4 times per day, 15 to 30 minutes before meals and, if necessary, before retiring. Children 5 to 12 years old: One tablet (10 mg) 3 to 4 times per day, 15 to 30 minutes before meals and, if necessary, before retiring. Chronic conditions (mainly dyspepsia) Adults: One tablet (10 mg) taken 3 times per day, 15 to 30 minutes before meals and, if necessary, before retiring. The dosage may be doubled. Children 5 to 12 years old: ˝ tablet (5 mg) 3 to 4 times per day, 15 to 30 minutes before meals and if necessary, before retiring. This formulation is not suited for children under the age of 5 years, but for this group of patients the suspension is available. MOTILIUM should be used with caution in patients with renal impairment or in those at risk of fluid retention. In patients with severe renal insufficiency ( serum creatinine more than 6 mg/100 mL, ie. more than 0,6 mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should be reduced to once or twice daily, depending on the severity of impairment, and the dose may need to be reduced. Patients on prolonged therapy should be reviewed regularly.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS Side-effects Allergic reactions, such as rash or urticaria, have been reported. Abdominal cramps have been reported. Dystonic reactions (extrapyramidal phenomena) may occur. Reversible raised serum prolactin levels have been observed which may lead to galactorrhoea and gynaecomastia. Hypertensive crises in patients with phaeochromocytoma may occur with administration of domperidone. Where the blood brain barrier is not fully developed (mainly in young babies) or is impaired, the possible occurrence of neurological side-effects cannot be totally excluded. Special precautions Since domperidone is highly metabolised in the liver, MOTILIUM should be used with caution in patients with hepatic impairment (and in the elderly). Interactions Concomitant administration of anti-cholinergic drugs may inhibit the anti-dyspeptic effects of MOTILIUM. Anti-muscarinic agents and opioid analgesics may antagonise the effect of MOTILIUM. MOTILIUM suppresses the peripheral effects (digestive disorders, nausea and vomiting) of dopaminergic agonists. Since MOTILIUM has gastro-kinetic effects, it could influence the absorption of concomitant orally administered medicines, particularly those with sustained release or enteric coated formulations. As MOTILIUM interferes with serum prolactin levels, it may interfere with other hypoprolactinaemic agents and with some diagnostic tests. Antacids and anti-secretory agents lower the oral bioavailability of domperidone. They should be taken after meals and not before meals, i.e. they should not be taken simultaneously with MOTILIUM. Reduced gastric acidity impairs the absorption of domperidone. Oral bioavailability is decreased by prior administration of cimetidine or sodium bicarbonate. The main metabolic pathway of domperidone is through CYP3A4. In vitro data suggests that concomitant use of drugs that significantly inhibit this enzyme may result in increased plasma levels of domperidone. Examples of CYP3A4 inhibitors include the following: - azole antifungals - macrolide antibiotics - HIV protease inhibitors - nefazodone
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT Symptoms of overdosage may include drowsiness, disorientation and extrapyramidal reactions especially in children. Anticholinergic, anti-Parkinson medicines or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactions. There is no specific antidote to domperidone but in the event of overdosage, gastric lavage as well as the administration of activated charcoal may be useful. Symptomatic and supportive measures are recommended.
IDENTIFICATION White circular, biconvex, film-coated tablet with a 6,5 mm diameter engraved "M" above "10" on one side and "JANSSEN" on the other side.
PRESENTATION Cartons containing one or more blister packs of 10, 20 or 25 tablets each.
STORAGE INSTRUCTIONS Store below 25°C. Protect from light. KEEP OUT OF REACH OF CHILDREN.
REGISTRATION NUMBER K/5.7.2/261
NAME AND BUSINESS ADDRESS OF THE APPLICANT JANSSEN - CILAG logo
JANSSEN PHARMACEUTICA (PTY) LTD (Reg. No. 1980/011122/07) 15th Road HALFWAY HOUSE 1685 © JPH (PTY) LTD SA 1990
DATE OF PUBLICATION OF THIS PACKAGE INSERT 30 July 1990 Code No.:024092 2001C Britepak
® =Trademark
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Right now, from what I have been able to gather in the boards, Domperidone is not allowed into the states. It is mainly used to treat people with Gastroparesis. A terrible sad disease.
There have been some posts on it in the past, I don't think this med is a reason for either one of us to get into a discussion on this subject. Glad neither of us have Gastroparesis. TAke care, gayla
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is that I just read an older post from AmandaPanda and she mentioned when she went to London she could get something called "Motilium 10" from Boots (a drug mart/pharmacy) meaning no prescription - yet its available in Canada by prescription and not in the US at all...gosh, everything just clicked now. i totally remember that old post and all the controversy. oy...
but my point is just that it contains the same ingredients and it is supposed to help gas/bloating and to regulate the gut. Heres the website. Take care too!
web page
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Just so you are aware it can cause you to lactate. While I was taking it no one warned me and needless to say I got just a little freaked out. Some it effects worse than others so I hope you are one that is doesn't. I have heard of it making some people very antsy but that isn't very common at all. Most do very well on the drug with little or no side effect. You may experiance headaches at first but that will go away. It is also a drug that has to build up in the system before you notice any effect, about 4 weeks or so. From first hand experiance I can tell you it does help the tummy I don't know how it will work on the C as that wasn't a problem for me but I do wish you the best of luck.
Take Care,
Bonnie
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Librax
#87614 - 07/07/04 11:38 PM
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Vicam
Reged: 02/24/04
Posts: 1955
Loc: Ontario, Canada
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Hey,
I thought I'd just post in answer to your question about Librax. It's a combination of an anti-anxiety/sedative type drug and an anti-spasmodic. It's generally used in the treatment of IBS and peptic ulcer (from what I've read). Because it's from the benzodiazepen (sp?) family it can be potentially addictive, so some doctors are reluctant to prescribe it.
I don't know how it would work for a C person...if your C is triggered by stress and anxiety I would imagine it would help, although I believe one of the possible side effects is constipation.
Hope that helps Kelly
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